Taner Karagöl

Welcome!

I am Taner Karagöl, a researcher dedicated to decoding the molecular architecture of life to solve critical challenges in human disease.

My work integrates structural biology, molecular pathways, genomics, and other fields of bio-medical research to reveal disease mechanisms and develop innovative therapeutic approaches.

I conduct structural research with Shuguang Zhang at the Massachusetts Institute of Technology (MIT) and contribute to genomic research with UCL Medical School (Prof. Steven J Perkins at UCL). I am a Final-Year MD Candidate at Istanbul University.

You can find more detailed information here:

About me

Research areas

Macromolecule Structure
& Design

-Protein Engineering: Design of environmental variants and inhibitory isoforms. -Structure-Based Drug Design: 3D structure predictions, MMGBSA, MMPBSA, and binding predictions. -Membrane Biophysics: MD simulations of lipid-protein conformational dynamics. -Oligomers & Lipid Interactions: Modeling neuronal assemblies and membrane distortions.

Genomics
& Molecular Evolution

-Clinical Genomics: Locus-specific variant databases (Haemophilia, Glutamate). -Evolutionary Medicine: Purifying selection and Shannon entropy modeling. -Mutational Profiling: Analysis of V>A>T pathways and genetic code architecture. -Transcriptomics: Ancient RNA conservation and splice-altering variations.

Medicine
& Methodology

- Neuroscience & Immunology: Disease-involved proteins and immune response pathways. -Statistical Medicine & AI: Open science automation workflows, AI models. -Software & Tool Development: Creation of toolkit and bioinformatics pipelines. -Theoretical Biology: Models to predict biological competition.